Megan Mullally is best known for playing the iconic role of Karen Walker on the groundbreaking hit TV series Will & Grace for which she won two Emmy Awards, from a total of seven consecutive nominations between 2000 and 2006. She made her Broadway debut as Marty in the 1994 revival of Grease with Rosie O'Donnell and subsequently appeared as Rosemary in the hit 1995 revival of How to Succeed in Business Without Really Trying opposite Matthew Broderick. In 2007, Mullally starred as Elizabeth in Mel Brooks' original Broadway musical, Young Frankenstein. She can be heard on the cast albums of all three productions. She appeared off-Broadway with her husband Nick Offerman in Sharr White’s play Annapurna. 

In addition to her breakout role on Will & Grace, Megan Mullally has starred as Lydia on the Starz series Party Down and as Chief on all five seasons of two-time Emmy-winning comedy series Children’s Hospital. She has also appeared frequently on Parks and Recreation, Bob’s Burgers and Web Therapy. Megan made her television debut in 1986 in The Ellen Burstyn Show. Since that time she has appeared on Seinfeld, Frasier, Wings, Ned and Stacey, Mad About You, Caroline in the City, Just Shoot Me!, and Murder, She Wrote. Following Will & Grace, she hosted her own talk show titled The Megan Mullally Show, and has hosted Saturday Night Live, the TV Land Awards, and guest-hosted The Late Show with David Letterman. Other TV appearances include 30 Rock, Kathy Griffin: My Life on The D-List, Campus Ladies, ABC’s Happy Endings, and Fox TV’s Breaking In. Her recent film work includes Smashed, Kings of Summer, GBF, Trouble Dolls, Anywhere But Here with Susan Sarandon and Natalie Portman, About Last Night with Demi Moore and Rob Lowe, Speaking of Sex with James Spader, Stealing Harvard with Tom Green and Jason Lee, and the 2009 remake of Fame.